Kratom Use and Toxicities in the United States

Kratom is an herbal supplement containing alkaloids with opioid properties. Kratom use is increasing and is associated with significant toxicities. Our findings suggest kratom is not reasonably expected to be safe and poses a public health threat due to its availability as an herbal supplement. Kratom most commonly caused agitation, tachycardia, drowsiness, vomiting, and confusion. Read More →

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Brea Neri
Changes in HIV Preexposure Prophylaxis Awareness and Use Among Men Who Have Sex with Men — 20 Urban Areas, 2014 and 2017

From 2014 to 2017, PrEP awareness among men who have sex with men (MSM) in 20 urban areas increased from 60% to 90%, and PrEP use increased from 6% to 35%. PrEP use increased in almost all demographic subgroups but remains lower among black and Hispanic MSM. By routinely testing patients for HIV, assessing HIV-negative patients for risk behaviors, and prescribing PrEP as needed, health care providers can play a critical role in ending the HIV epidemic. Read More →

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Brea Neri
Data Note: Public Awareness Around Antibiotic Resistance

While three-quarters of the public are aware that bacterial infections can usually be cured with antibiotics, over half either incorrectly say that viral infections can be cured using antibiotics (27%) or that they do not know enough to say (28%). Nearly half of adults (45%) say they have personally not taken their antibiotics as prescribed by a doctor – one of the leading causes of antibiotic resistance. Read More →

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Brea Neri
Antidepressants reduced risk of mortality in patients with diabetes mellitus: a population-based cohort study in Taiwan

Most antidepressants including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, norepinephrine-dopamine reuptake inhibitors, mirtazapine, tricyclic/tetracyclic antidepressants, and trazodone were associated with significantly reduced mortality among population with comorbid DM and depression. Read More →

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Brea Neri
FDA Approves AirDuo Digihaler

FDA approved AirDuo® Digihaler™ (fluticasone propionate 113 mcg and salmeterol 14 mcg) Inhalation Powder, a combination therapy digital inhaler with built-in sensors that connects to a companion mobile application to provide information on inhaler use to people with asthma. AirDuo Digihaler is indicated for the treatment of asthma in patients aged 12 years and older. Read More →

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Brea Neri
FDA Approves Katerzia

FDA approved Katerzia (amlodipine) Oral Suspension, 1 mg/mL, the first and only FDA-approved amlodipine oral suspension. Katerzia is indicated for the treatment of hypertension (high blood pressure) in adults and pediatric patients 6 years of age and older and coronary artery disease in adults. Read More →

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Brea Neri
Walgreens expands safe drug disposal to all pharmacies

Walgreens said it is expanding its safe drug disposal program to provide year-round drug disposal options in all of its pharmacies nationwide, at no cost to customers. All Walgreens pharmacies that do not currently offer a safe medication disposal kiosk now offer DisposeRx packets or other drug disposal options, available upon request for customers, to safely discard unwanted medications at home. Read More →

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Brea Neri
Durability of insulin degludec plus liraglutide versus insulin glargine U100 as initial injectable therapy in type 2 diabetes (DUAL VIII)

The Lancet - In patients with uncontrolled type 2 diabetes on oral antidiabetic drugs, initial injectable therapy with insulin degludec plus liraglutide resulted in fewer patients reaching the treatment intensification criterion during 104 weeks versus insulin glargine 100 units/mL, with longer durability of the treatment effect with insulin degludec plus liraglutide. Read More →

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Brea Neri
Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden

BMJ - This study suggests that gabapentinoids are associated with an increased risk of suicidal behavior, unintentional overdoses, head/body injuries, and road traffic incidents and offences. Pregabalin was associated with higher hazards of these outcomes than gabapentin. Read More →

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Brea Neri
Anticholinergic Drug Exposure and the Risk of Dementia

Exposure to several types of strong anticholinergic drugs including anticholinergic antidepressants, antiparkinson drugs, antipsychotic drugs, bladder antimuscarinics, and antiepileptic drugs is associated with an increased risk of dementia. These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people. Read More →

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Brea Neri