The Lancet - Dulaglutide could be considered for the management of glycemic control in middle-aged and older people with type 2 diabetes with either previous cardiovascular disease or cardiovascular risk factors. Read More →
Read MoreLong-term use of dulaglutide was associated with reduced composite renal outcomes (first occurrence of new macroalbuminuria (UACR >33·9 mg/mmol), a sustained decline in eGFR of 30% or more from baseline, or chronic renal replacement therapy) in people with type 2 diabetes. Read More →
Read MoreCRP-guided prescribing of antibiotics for exacerbations of COPD in primary care clinics resulted in a lower percentage of patients who reported antibiotic use and who received antibiotic prescriptions from clinicians, with no evidence of harm. Read More →
Read MoreNovartis has said both the adult and pediatric doses of Symjepi (pre-filled epinephrine injenction) would be immediately available in local U.S. pharmacies. The wholesale price for a two-pack of adult-dose syringes is $250, below the $300 charged by Mylan for its authorized generic and for Teva’s generic version of the EpiPen auto-injector. Read More →
Read MoreKratom is an herbal supplement containing alkaloids with opioid properties. Kratom use is increasing and is associated with significant toxicities. Our findings suggest kratom is not reasonably expected to be safe and poses a public health threat due to its availability as an herbal supplement. Kratom most commonly caused agitation, tachycardia, drowsiness, vomiting, and confusion. Read More →
Read MoreFrom 2014 to 2017, PrEP awareness among men who have sex with men (MSM) in 20 urban areas increased from 60% to 90%, and PrEP use increased from 6% to 35%. PrEP use increased in almost all demographic subgroups but remains lower among black and Hispanic MSM. By routinely testing patients for HIV, assessing HIV-negative patients for risk behaviors, and prescribing PrEP as needed, health care providers can play a critical role in ending the HIV epidemic. Read More →
Read MoreWhile three-quarters of the public are aware that bacterial infections can usually be cured with antibiotics, over half either incorrectly say that viral infections can be cured using antibiotics (27%) or that they do not know enough to say (28%). Nearly half of adults (45%) say they have personally not taken their antibiotics as prescribed by a doctor – one of the leading causes of antibiotic resistance. Read More →
Read MoreMost antidepressants including selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, norepinephrine-dopamine reuptake inhibitors, mirtazapine, tricyclic/tetracyclic antidepressants, and trazodone were associated with significantly reduced mortality among population with comorbid DM and depression. Read More →
Read MoreFDA approved AirDuo® Digihaler™ (fluticasone propionate 113 mcg and salmeterol 14 mcg) Inhalation Powder, a combination therapy digital inhaler with built-in sensors that connects to a companion mobile application to provide information on inhaler use to people with asthma. AirDuo Digihaler is indicated for the treatment of asthma in patients aged 12 years and older. Read More →
Read MoreFDA approved Katerzia (amlodipine) Oral Suspension, 1 mg/mL, the first and only FDA-approved amlodipine oral suspension. Katerzia is indicated for the treatment of hypertension (high blood pressure) in adults and pediatric patients 6 years of age and older and coronary artery disease in adults. Read More →
Read MoreNew study assessed the association between exposure to monotherapy with 10 different antiepileptic drugs during the first 2 months of pregnancy. The results confirmed the teratogenicity of valproic acid and topiramate. They found no significant association for lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, and gabapentin. Read More →
Read MoreThe FDA requires autoinjector expiration dates to ensure that the devices never contain less than 90% of the original dose of epinephrine. All of the autoinjectors tested that were up to 30 months beyond their labeled expiration date still had at least 90% of the dose remaining. Read More →
Read MoreAmong persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D3 supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo. Read More →
Read MoreWomen 80 years and older with osteoporosis, including those with more comorbidities or poorer prognosis, have a high hip fracture probability despite accounting for competing mortality risk and may be the group most likely to be candidates for drug treatment to prevent hip fractures. Read More →
Read MoreConsumption of dietary supplements sold for weight loss, muscle building, and energy involved increased risks for severe medical events compared with vitamins. Proactive enforcement of regulations is needed to reduce access and consumption among children, adolescents, and young adults. Read More →
Read MoreWalgreens said it is expanding its safe drug disposal program to provide year-round drug disposal options in all of its pharmacies nationwide, at no cost to customers. All Walgreens pharmacies that do not currently offer a safe medication disposal kiosk now offer DisposeRx packets or other drug disposal options, available upon request for customers, to safely discard unwanted medications at home. Read More →
Read MoreAAP - Infant PPI use alone (21% increase) and together with H2RAs (30% increase) is associated with an increased childhood fracture hazard, which appears amplified by days of use and earlier initiation of ASTs. H2RA use alone did not increase risk. Use of AST in infants should be weighed carefully against possible fracture. Read More →
Read MoreThe Lancet - In patients with uncontrolled type 2 diabetes on oral antidiabetic drugs, initial injectable therapy with insulin degludec plus liraglutide resulted in fewer patients reaching the treatment intensification criterion during 104 weeks versus insulin glargine 100 units/mL, with longer durability of the treatment effect with insulin degludec plus liraglutide. Read More →
Read MoreBMJ - This study suggests that gabapentinoids are associated with an increased risk of suicidal behavior, unintentional overdoses, head/body injuries, and road traffic incidents and offences. Pregabalin was associated with higher hazards of these outcomes than gabapentin. Read More →
Read MoreExposure to several types of strong anticholinergic drugs including anticholinergic antidepressants, antiparkinson drugs, antipsychotic drugs, bladder antimuscarinics, and antiepileptic drugs is associated with an increased risk of dementia. These findings highlight the importance of reducing exposure to anticholinergic drugs in middle-aged and older people. Read More →
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