Taking into account both efficacy and safety, evidence from this meta-analysis supports methylphenidate in children and adolescents, and amphetamines in adults, as preferred first-choice medications for the short-term treatment of ADHD. Read More →
Read More10% of all patients in the US claim to have a penicillin allergy. Of those people, 90% are not truly allergic and can tolerate the drug. That means millions of people take alternative antibiotics, which are more expensive and can put their health and potentially the health of others at risk. Read More →
Read MoreAmong patients with mild to moderate hypertension, treatment with a pill containing low doses of 3 antihypertensive drugs (20mg telmisartan, 2.5mg amlodipine, and 12.5mg chlorthalidone) led to an increased proportion of patients achieving their target BP goal vs usual care. Use of such medication as initial therapy or to replace monotherapy may be an effective way to improve BP control. Read More →
Read MoreOne‐quarter of U.S. older adults (75 years or older) with type 2 diabetes mellitus are tightly controlled (HbA1c < 7%) with glucose‐lowering medications that have a high risk of hypoglycemia (insulin, sulfonylurea, or meglitinide). These results suggest potential overtreatment of a substantial proportion of people and should encourage further efforts to translate guidelines to daily practice. Read More →
Read MoreFor the first time in more than eighteen years, the U.S. FDA approved a new drug for the prevention of malaria. ARAKODA™ is supplied in 100 mg tablets for oral use only. After an initial loading dose prior to traveling, ARAKODA™ is intended to be taken once a week which could offer convenience to the traveler. Read More →
Read MoreThe FDA has approved Annovera (segesterone acetate and ethinyl estradiol vaginal system), a combined hormonal contraceptive for women of reproductive age used to prevent pregnancy and is the first vaginal ring contraceptive that can be used for an entire year. Annovera is placed in the vagina for three weeks followed by one week out of the vagina. Read More →
Read MoreWestminster Pharmaceuticals voluntarily recalled all lots, within expiry, of Levothyroxine and Liothyronine (Thyroid Tablets, USP) 15 mg, 30 mg, 60 mg, 90 mg, & 120 mg. These products are being recalled as a precaution because they were manufactured using active pharmaceutical ingredients that were sourced prior to the FDA’s Import Alert of Sichuan Friendly Pharmaceutical Co., Ltd., which as a result of a 2017 inspection were found to have deficiencies with Current Good Manufacturing Practices (cGMP). Read More →
Read MoreThe prevalence of opioid use disorder more than quadrupled during 1999–2014 (from 1.5 per 1,000 delivery hospitalizations to 6.5). There is continued need for national, state, and provider efforts to prevent, monitor, and treat opioid use disorder among reproductive-aged and pregnant women, including better access to data in state prescription drug monitoring programs, increased screening for substance use disorders, use of medication-assisted therapy, and referrals for treating substance use disorders. Read More →
Read MoreStudy showed that at low and high doses, semaglutide (Ozempic) was superior to dulaglutide (Trulicity) in improving glycemic control and reducing bodyweight, enabling a significantly greater number of patients with type 2 diabetes to achieve clinically meaningful glycemic targets and weight loss, with a similar safety profile. Read More →
Read MoreAntihistamines are widely used for the treatment of AD. There is no high-level evidence to suggest that non-sedating antihistamines reduce itch in patients with AD, or that sedating antihistamines provide benefit in controlling AD symptoms (except perhaps sleep and AD co-morbidities, such as allergic rhinitis). Read More →
Read MoreA large population based cohort study, canagliflozin (Invokana) was associated with a 30% to 49% decreased risk of heart failure admission to hospital and with a similar risk of myocardial infarction or stroke as compared with three other non-gliflozin antidiabetic drugs (DPP-4 inhibitor, GLP-1 receptor agonist, sulfonylurea) as used in routine care. Read More →
Read MoreDietary supplementation is approximately a $30 billion industry in the United States, with more than 90 000 products on the market. In recent national surveys, 52% of US adults reported use of at least 1 supplement product, and 10% reported use of at least 4 such products.1 Vitamins and minerals are among the most popular supplements and are taken by 48% and 39% of adults, respectively, typically to maintain health and prevent disease.
Despite this enthusiasm, most randomized clinical trials of vitamin and mineral supplements have not demonstrated clear benefits for primary or secondary prevention of chronic diseases not related to nutritional deficiency. Indeed, some trials suggest that micronutrient supplementation in amounts that exceed the recommended dietary allowance (RDA)—eg, high doses of beta carotene, folic acid, vitamin E, or selenium—may have harmful effects, including increased mortality, cancer, and hemorrhagic stroke. Read More →
Read MoreChanges in the 2018 adult immunization schedule (effective February 2018) from the previous year’s schedule include new ACIP recommendations for the use of recombinant zoster vaccine (RZV) for adults aged 50 years or older and the use of an additional dose of measles, mumps, and rubella vaccine (MMR) in a mumps outbreak setting. Read More →
Read MoreChanges in the 2018 immunization schedules for children and adolescents aged 18 years or younger (effective February 2018) include new or revised ACIP recommendations for poliovirus, influenza, and measles, mumps, and rubella vaccines, and clarification of the recommendations for rotavirus and pneumococcal vaccines. Read More →
Read MoreThis meta-analysis of 10 trials involving 77 917 participants demonstrated that supplementation with marine-derived omega-3 fatty acids for a mean of 4.4 years had no significant association with reductions in fatal or nonfatal coronary heart disease or any major vascular events. Read More →
Read MoreBrief primary care CBT among youth declining AD therapy is cost-effective by widely accepted standards in depression treatment. CBT becomes dominant over TAU over time, as revealed by a statistically significant cost offset at the end of the 2-year follow-up. Read More →
Read MoreSleep doesn’t come easily for nearly half of older Americans, and more than a third have resorted to some sort of medication to help them doze off at night, according to new results from the National Poll on Healthy Aging.
But most poll respondents said they hadn’t talked to their doctor about their sleep, even though more than a third said their sleep posed a problem. Half believe - incorrectly - that sleep problems just come naturally with age. The poll was conducted by the University of Michigan Institute for Healthcare Policy and Innovation, and is sponsored by AARP and Michigan Medicine, U-M’s academic medical center. Read More →
Read MoreThe United States Drug Enforcement Administration today announced a deregulatory measure that will make it easier for residents of underserved areas to receive treatment for opioid addiction. Read More →
Read MoreIn November 2017, the American College of Cardiology (ACC) and the American Heart Association (AHA) released a clinical practice guideline for the prevention, detection, evaluation, and treatment of high blood pressure (BP) in adults. This article summarizes the major recommendations. Read More →
Read MoreBoth terbinafine and azole-based medications were associated with higher clinical and mycological cure rates compared with placebo (high-quality evidence). Azoles were associated with lower cure rates than terbinafine when compared directly. Read More →
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